With regard to the number of retrieved oocytes, HCG, oestradiol and GH treatments had the highest number of oocytes retrieved. Compared with controls, DHEA and CoQ10 treatments resulted in a significantly higher chance of clinical pregnancy. Of the 1124 studies initially identified, 46 trials reporting on 6312 women were included in this systematic review, while 19 trials defining POR using the Bologna criteria reporting 2677 women were included in the network meta-analysis. This review protocol was registered with PROSPERO (CRD42018086217). We measured study quality based on the methodology and categories listed in the Cochrane Collaboration Handbook. The administration of GnRH analogs and gonadotrophins without adjuvant treatment was set as the control. We included studies that investigated various adjuvant agents, including androgen and androgen-modulating agents, oestrogen, progesterone, clomiphene citrate, GH and CoQ10, during IVF treatment and reported subsequent pregnancy outcomes. Relevant studies published in the English language were comprehensively selected using PubMed, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL) until 11 July 2018. Randomized controlled trials (RCTs) comparing 10 adjuvant treatments were included. The aim of this systemic review is to evaluate the role of different adjuvant treatment strategies on the probability of pregnancy achievement in poor responders undergoing IVF. Despite great advances in assisted reproductive technology, poor ovarian response (POR) is still considered as one of the most challenging tasks in reproductive medicine.
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